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Furthermore, its antioxidant properties offer protection against oxidative stress, while its modulation of growth hormone receptors hints at potential longevity benefits

What Is an Ex Vivo Study

In vivo experiments further demonstrated that Irisin-loaded bone marrow mesenchymal stem cell-derived exosomes significantly inhibited activation of the YAP/EGR1/ACSL4 signaling pathway in the brains of middle cerebral artery occlusion (MCAO) mice, suppressed ferroptosis and lipid peroxidation, thereby mitigating ischemic brain injury ( In vitro experiments further confirmed that FGF21 protected HT22 cells from OGD/R-induced oxidative stress and ferroptosis, thereby attenuating neuronal injury (Zhao et al., 2025c)

Primary endpoints: TRAP telomerase activity

To expand the prognostic application, a risk stratification model based on these enzymes was developed using the LASSO Cox regression algorithm