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In 2025 , Novo Nordisk announced positive Phase 3 ESSENCE trial results evaluating semaglutide for early Alzheimers disease, demonstrating potential neuroprotective effects and opening new therapeutic opportunities
Additionally, GLP-1 suppresses glucagon secretion from pancreatic alpha cells, slows gastric emptying to moderate the rate at which nutrients enter the bloodstream, and acts on the brain to promote satiety and reduce appetite
Tremblay A, Bellisle F
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