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It also interacts with melanocortin receptors, particularly MC1R, which are expressed on immune cells including macrophages, dendritic cells, and T cells
Cancer Cell 35 , 177190 (2019)
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In this case, the variant causes the transport of the metabolite of a chemotherapy drug not to work correctly, increasing side effects.[ref] Related article : Trimethylaminuria: Gene variants that cause a bad body odor Variants in the FMO3 gene can cause a fishy or icky-smelling odor (listed below in the Lifehacks section)
In laboratory and pre-clinical research settings, glutathione is studied across virtually every area of cellular biology owing to its central, non-redundant role in redox homeostasis and its interactions with dozens of enzyme systems, signalling pathways, and disease-relevant biological processes
