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Most patients return to normal activity within a few hours

doi: 10.3390/nu17030503 23 MittelmanSD

Conversely, evening or bedtime administration may benefit some patients who find that sleeping through the initial hours after injection helps them avoid or minimize awareness of nausea

Some providers use 5 mg as a starting dose for patients on high-dose semaglutide, but this increases nausea risk and is not supported by published protocols