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Key findings from the trial (Jastreboff et al., NEJM 2023) included: Placebo group : Mean body weight reduction of approximately 2.1% from baseline at 48 weeks
437 For young patients with obvious tremors, anticholinergic drugs need to be used cautiously
This bidirectional regulation suggests sophisticated sensing of tissue microenvironmental cues, enabling GHK-Cu to normalize MMP activity toward homeostatic levels rather than exerting uniform stimulatory or inhibitory effects
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