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Although the carboxyl-molecules can be made to react directly with amines using EDC, the reaction is much more efficient with NHS because a stable intermediate is created
In addition, brain mapping shows that AgRP neurons interact with POMC neurons in the ARC through the inhibitory neurotransmitter -amino butyric acid (GABA)
The work supports the broader HGF/c-Met mechanism beyond the hippocampal cognitive context, and the zebrafish protection model has been further studied in subsequent work in mammalian systems
Stewart SE, Yu D, Scharf JM, et al
