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[11] [12] [13] No medical uses for MSM have been approved and there is limited evidence to support most of the claims

12 Because its oxidative functions require GSH to be in its reduced form, GSSG is reduced to regenerate GSH in a reaction catalyzed by GSH reductase that requires reduced nicotinamide adenine dinucleotide phosphate (NADPH) as a hydrogen donor (Figure 2)

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