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Whilst direct pharmacological interactions between amoxicillin and Wegovy are not documented, several clinical considerations warrant attention when taking these medications concurrently

The other reason is related to your body going through a detoxification process

Journal of Pharmacology and Experimental Therapeutics, 2002, 302(3): 881-888

Desiree Granados Quick Summary: Semaglutide can be associated with fatigue in some individuals, potentially related to gastrointestinal side effects, changes in appetite and blood sugar regulation, or adjustments in energy metabolism