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All statistical tests were performed by using GraphPad Prism 5.0 software (GraphPad, Dotmatics, Bishops Stortford, United Kingdom)

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Discussion The population pharmacokinetic model reported here successfully describes the pharmacokinetics of semaglutide, reproducing the values for CL/F and V/F of approximately 0.05 l/h and 12.5 l, respectively, obtained from clinical pharmacology trials with richly sampled PK profiles in subjects with T2DM (Novo Nordisk, data on file)

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