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Informed by the structural data of Pt GSTF8, the accompanying mutagenesis experiments and the QM/MM studies, we investigated the impact of a disulfide bond between C13 and GSH on dehydratase activity
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have noted, conventional safety studies undertaken in animals provide only limited prediction of liver injury that may be caused by new investigational drugs in humans (Olson et al
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However, human clinical data on these wider applications are still preliminary
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