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There might be a compensatory relationship between incretin receptors and how GIP-receptor antagonism can enhance GLP-1 receptor activity

For example, if a patient presents with elevated GH and IGF-I, it is important to rule out underlying impairment in renal function as elevated serum GH and IGF-I levels may also be present in patients with CKD, and not diagnose the patient as having acromegaly

Anenberg, E., Chan, A

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