ABSTRACT: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual glucose-dependent insulinotropic polypeptide/GLP-1 RAs are common therapies for managing diabetes and obesity, but gastrointestinal (GI) adverse effects (AEs) such as nausea, vomiting, diarrhea, and constipation frequently limit therapy
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These molecules activate two metabolic hormone receptors at once, most commonly: GLP-1 + GIP GLP-1 + glucagon Dual-agonist peptides demonstrated how combining hormone pathways might produce broader metabolic signaling compared to single-pathway compounds