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It is contraindicated for weight management during pregnancy (Zepbound), and women of reproductive potential should be counseled about potential effects on oral contraceptive efficacy

Water, L-carnitine (0.4%), hydrolysed collagen, acidity regulator: citric acid, flavouring, green tea extract (0.1%), sweetener acesulfame K, vitamins (B-group vitamins, vitamin C), preservatives: potassium sorbate and sodium benzoate

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At the end of 40 or 42 weeks (study time varied by trial), urine albumin-to-creatinine ratio (UACR) was significantly reduced among participants assigned to tirzepatide 5, 10, or 15 mg as compared with those assigned to all pooled comparators (placebo, semaglutide, insulin degludec, and insulin glargine) with adjusted mean percent changes of 19.3% [95% CI 12.525.5%], 22.0% [95% CI 15.328.1%], and 26.3% [95% CI 20.032.0%], respectively, with a greater reduction observed in participants with a UACR 30 mg/g at baseline [96]

However, research conducted with rams has shown promising results regarding the use of RPM supplementation, which may serve as a valuable reference for future studies in other species, including cattle