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doi: 10.1016/s0304-3835(01)00797-2 72 XinHDengYCaoJ

By meta-analysis of the individual cardiovascular endpoints, significant improvements were established for all of the following: myocardial infarction, stroke, cardiovascular mortality, all-cause mortality and hospitalisation for heart failure

From a clinical perspective, unexplained loss of glycemic control or weight loss plateau after previously good response may suggest medication issues, though this requires careful differential diagnosis

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