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It undergoes hepatic metabolism to the active metabolite desipramine, which preferentially inhibits norepinephrine reuptake
246 Other contexts include IL-11mediated activation of JAK1/STAT4 in prostate cancer, where nuclear pSTAT4 enhances c-MYC transcription, conferring docetaxel resistance
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If nausea persists, trying pre-bed dosing is an option, though this may slightly reduce efficacy by separating the peptide from morning cortisol elevation
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