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doi: 10.1111/j.1365-2265.2009.03697.x 226 SinghSDuggalJMolnarJMaldonadoFBarsanoCPAroraR

doi: 10.1507/endocrj.43.suppl_s57 54 MllerNJrgensenJOL

This is in part due to the fact that the amino acids glutamate and proline can easily substitute for many of the metabolic roles of glutamine, including energy production and amino acid synthesis

This promotes Nrf2 nuclear translocation and ARE binding, upregulating antioxidant enzymes such as Superoxide Dismutase 1(SOD1), Heme Oxygenase-1(HO-1), and Glutathione Peroxidase (GPx) (Wang et al., 2020

5 In vitro organ protection effects of ISO The in vitro antitumor activities of ISO are described in detail above (Table 4), while the potential in vitro organ protective effects of ISO are reviewed in the following sections