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Researchers have already tested a range of doses and escalation schedules, providing valuable insight into how treatment may start, increase, and be maintained
It can temporarily overwhelm the kidneys' ability to filter out the sudden influx of uric acid, causing serum levels to spike
Slower Titration to Reduce Side Effects Increasing doses too quickly can lead to more severe side effects such as nausea, vomiting, dehydration, and even discontinuation of treatment
Slowed gastric emptying: Food stays in the stomach longer, prolonging fullness after meals
We measured oxidative stress levels through malondialdehyde (MDA), a naturally occurring product of lipid peroxidation, and an established marker for oxidative stress
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