This cycle may look like: Experiencing initial weight loss and minimizing side effects
However, the transition period may involve fluctuating urinary patterns as metabolic balance is restored
- Heavy training on the injured knee during weeks 1-4
Underlying medical conditions: Certain conditions can blunt weight loss responses, including hypothyroidism (a thyroid function test is advisable if not recently checked), Cushing's syndrome or exogenous corticosteroid use, polycystic ovary syndrome (PCOS), and obstructive sleep apnoea (OSA)
Within-class differences further inform selection, as GLP-1RAs are more strongly associated with reductions in atherosclerotic events, while SGLT2is demonstrate greater benefit in HF and kidney outcomes, with modest blood pressure-lowering effects that may contribute to cardiovascular risk reduction [9]