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With chronic overexposure, they cause tissue degradation

Lean mass preservation and modest gains

and Rosenbloom et al., highlighting the potential of intranasal delivery as a therapeutic approach for DS patients

Moreover, lipid nanocapsules (LNCs) loaded with load-laurylated gemcitabine (GemC12) can effectively target the monocytic (M-) MDSC subset, and subcutaneous injection of GemC12-loaded LNCs can enhance tumor immunotherapy by reducing the proportion of M-MDSCs in splenic and tumor-infiltrating monocytes, with efficacy higher than that of free gemcitabine (120)

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