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Identifying and understanding rare side effects like dysesthesia and allodynia is part of the ongoing process of optimizing patient care with these powerful medications

While the relevance of these findings to human risk remains uncertain due to differences in receptor expression between species, they prompted the inclusion of Boxed Warnings on medication labels

Compound-level evidence does not automatically validate the blend

Your PT may use visualization cues, manual techniques, or biofeedback to help retrain these muscles and support better bowel habits over time

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