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At the epigenetic level, decreasing NAD + /NADH ratio with age inhibits SIRT1/3 activity and impairs PGC-1-mediated mitochondrial biosynthesis and antioxidant gene expression [292, 293]
Additionally, L-carnitine supplementation has a positive effect on fasting lipid profile since it led to a significant increase in HDL levels in pediatric patients on KDT
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Naseer et al
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