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Based on Phase 2 safety data (Jastreboff et al., NEJM 2023), common early adverse effects reported include: Nausea (the most frequently reported adverse effect) Vomiting Diarrhoea or constipation Reduced appetite Mild fatigue or dizziness These effects are consistent with the GLP-1 receptor agonist class and typically reflect the gut's adaptation to altered gastric emptying and hormonal signalling

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Neuroprotection by exendin-4 is GLP-1 receptor specific but DA D3 receptor dependent, causing altered BrdU incorporation in subventricular zone and substantia nigra

We observed, that patients who developed PHLF displayed 2.3-fold higher GLP-1 plasma concentrations preoperatively, compared to patients without PHLF ( p = 0.030)

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