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Both genetic circadian disruption and HFD feeding shifted adipocyte cell state from a pro-adipogenic signature towards an insulin resistant state 55,56

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For example, Bifidobacterium animalis F1-7 can upregulate acetylcarnitine levels in the gut, thereby downregulating the TLR4/NF-B pathway and reducing lipid accumulation and inflammation in foam cells, leading to a reduction in atherosclerotic plaque accumulation [129]

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