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Key limitations of the existing evidence include: Small sample sizes in many studies Heterogeneous patient populations Variable dosing regimens (typically 35 grams daily) Short follow-up periods (often 4-12 weeks) Inconsistent outcome measures Potential publication bias favouring positive results Some studies have investigated combination approaches

doi:10.3390/jcm10061202 [41] Berry-Kravis E, Booth G, Sanchez AC, Woodbury-Kolb J

Johnson KR, Erway LC, Cook SA, Willott JF, Zheng QY

[125] [126] Some studies have suggested that valproate may reopen the critical period for learning absolute pitch and possibly other skills such as language

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