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More recently, a randomized placebo-controlled trial on NS workers assessed melatonin supplementation before day sleep for four weeks, showing a significant increase in urinary 8-OHdG, biomarker of oxidative DNA damage repair, during day sleep 30
The deletion of ATF4, an upstream factor of ChaC1, in embryonic fibroblasts, results in a ferric oxide-dependent death phenotype, emphasizing the role of ATF4 as a downstream molecule of the eIF2/ATF4 pathway (117)