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The opposing effects of cannabinoids (either improving or worsening intestinal permeability) might be related to the recent observation that endocannabinoids such as anandamide worsen permeability while phytocannabinoids like cannabidiol and tetrahydrocannabidiol, which might act as (partial) CB1R antagonists, promote protection or recovery from intestinal permeability [52]
The majority of the subjects (83.6%) showed improvement in global wrinkle scores, skin elasticity (via cutometer) and skin texture, tone, and radiance after 3 months of treatment
The reduced thymosin alpha-1 levels correspond to measurable impairment in regulatory T cell function, and regulatory T cell dysfunction is a recognized driver of psoriasis pathology
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