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By contrast, cancer cells typically co-express MCT1 and MCT4, facilitating highly efficient lactate efflux that preserves intracellular pH homeostasis even within the acidic tumor microenvironment (127)
They demonstrated that a three-week supplementation of 1000 mg NR per day increased muscle NAD + metabolome, specifically NAAD and products of NAM clearance pathways, yet NAD + levels were not altered
Conversely, inhibiting mitophagy in cancer cells could exacerbate mitochondrial damage and induce cell death
Understanding that purging is normal (and often a sign the treatment is working) helps users push through this uncomfortable phase rather than abandoning treatment prematurely
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