The beneficial effects of GLP-1 receptor activation on glycemia occur through several mechanisms: GLP-1 stimulates glucose-dependent insulin secretion from pancreatic -cells, suppresses inappropriately elevated glucagon secretion from pancreatic -cells, delays gastric emptying, and induces satiety via a direct action in the central nervous system
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For instance, MC-1R appears linked to pigmentation, MC-2R to adrenal activity, MC-3R to metabolic regulation, and MC-5R to exocrine functions such as sweating and sebum production
Nagasawa M, Spits H, Ros XR