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Several studies have reported that the HGF/c-Met axis induces angiogenesis and cell growth through interaction with the VEGF and VEGFR pathway and decreasing expression of thrombospondin-1 (Zhang et al., 2003
It interacts with the dopaminergic system and appears to have neuroprotective properties
To establish the proportion of differentially expressed genes that were potentially regulated directly by GH, we compared the data by orthology with mouse genes identified as having STAT5 bound to putative regulatory elements by chromatin immunoprecipitation sequencing (ChIP:seq)
Biologically, there are reasons why it could support tissue repair, and clinically weve seen encouraging outcomes in some patients
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