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Description

Nrf2, a member of the capncollar family of basic regionleucine zipper transcription factors involved in transcription of antioxidant genes in response to xenobiotic stress, is also a critical regulator of cellular oxidative stress in sepsis (Kolls, 2006) and a regulator of exacerbated proinflammatory cytokine release (cytokine storm) and loss of T lymphocytes (leukopenia) that characterize the most aggressive presentation of SARS-CoV-2-mediated COVID-19 infection (Kobayashi et al., 2016

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These interactions strengthen the binding and function of GLP-2, consistent with the decreased potencies of R242A (by 5-fold), R242E (by 20-fold), W249A (by 1552-fold) and Y252A (by 5-fold) (Fig

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For a 5 mg vial reconstituted with 2.5 mL bacteriostatic water, the resulting concentration is 2 mg/mL

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