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These include changes within the cerebral cortex, reductions in grey matter volume, and increased amygdala volume (58)
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If muscle symptoms are severe or persistent despite these interventions, clinicians should consider laboratory evaluation including creatine kinase, comprehensive metabolic panel with separate magnesium and calcium testing, thyroid function tests, vitamin D levels, and vitamin B12 levels to exclude alternative diagnoses
The combination of semaglutide and regular alcohol may accelerate liver fat accumulation in susceptible individuals, though research is still emerging
