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Documented monitoring consideration: because new or darkening pigmented lesions are a documented effect (Minder et al., 2013), dermatology literature describes baseline and periodic skin checks for those on melanocortin agonists
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But if there are other outcomes that your patient is concerned about, then you have to consider the effect size for those other outcomes, Polley said
The cutoff points according to the ROC curve in the population after PSM may have a better predictive value
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