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The synthesis of PUFA-ePLs is associated with enzymes such as alkylglycerone phosphate synthase (AGPS) located in peroxisomes, fatty acyl-CoA reductase 1 (FAR1), glyceronephosphate O-acyltransferase (GNPAT), 1-acyl-sn-glycerol-3-phosphate acyltransferase 3 (AGPAT3) in the endoplasmic reticulum, and plasmalogen biosynthesis enzyme phytanoyl-CoA dihydroxyacetone phosphate acyltransferase (PEDS1)
Prior work has shown that depletion of KG, for instance via mutations in IDH1/2 that instead produce the oncometabolite D2-HG, inhibits KGDD activity leading to changes in DNA and histone methylation (Inoue et al., 2016
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