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Subsequent cell-based work has documented elevated intracellular NAD+ and increased sirtuin pathway activity following NNMT inhibition in adipocyte cultures

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There's also hope that retatrutide might have positive effects on heart health, making it potentially useful in managing heart disease complicated by diabetes, as well as heart disease in general

Should not be used in cases where the underlying condition is not due to Vitamin B12 deficiency, as it may not address other causes of symptoms