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The single-molecule approach (tirzepatide, retatrutide) offers advantages in simplicity and potentially in pharmacokinetics
The measurements were then converted into a percentage using the following formula: % of wound remaining = (measurement at time 12 hours/measurement at time 0 hours) 100
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Higher dilutions allow more accurate measurement of small doses
The clinical escalation protocol from the Phase 2 NEJM trial established a specific titration schedule that increases the dose every four weeks, starting low and building to a target maintenance dose
