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While the role of the cerebrovascular system in regulating nutrient transport to the brain and the impairments in glucose transport in E4s has been shown in both clinical populations and animal models (Reiman et al., 2005

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Due to the wide spread of HK-1 in the body, and its preferential affinity to the NK-1 tachykinin receptor, it has been implicated in many diseases (reviewed elsewhere, [103,104,105]) including asthma and possibly COPD [106,107,108]