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Participants maintained their weight loss at 6-month follow-up, suggesting the metabolic benefits persist beyond active treatment

Side effects are rare but may include fatigue or mild gastrointestinal discomfort

doi:10.1001/archotol.1993.01880180068013

For experiments involving caspase-3/7 staining, CellEvent Caspase-3/7 Green Detection Reagent (Thermo Scientific C10723) and CPP-CAND were added to live cells 24 h before imaging using an Eclipse Ti-U inverted microscope (NIKON)

Published results from a 2017 dose-ranging trial demonstrated that ARA-290 at 4 mg subcutaneously daily for 28 days met its primary endpoint: a significant placebo-corrected increase in corneal nerve fiber area an objective biomarker of small nerve fiber regeneration measured by confocal microscopy