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The effectiveness of GLP-1 receptor agonists in menopausal women is shaped by the broader hormonal environment within which they operate: whether estrogen has been restored, whether progesterone is supporting sleep quality and endometrial health, and whether testosterone decline is accelerating the muscle loss that weight reduction can compound

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The three GPX4 inhibitors displayed senolytic activity in SK-MEL-103 cells in which senescence had been induced by either etoposide, tozasertib or palbociclib treatment (Fig