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Also, researchers do not always ask about changes in menstrual cycles unless the study is focused on hormones or reproduction
That makes Pendulum a pick for biohackers or anyone ready to invest months, not days, for lasting metabolic stability
Leptin levels drop, increasing hunger signals
Clinical trials show that starting low reduces nausea rates by up to 40% compared to higher initial doses, making the first weeks more tolerable
It is still an effective obesity treatment and remains an NHS option in specialist weight management services
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