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Molecular effects of L-dopa therapy in Parkinsons disease
209 Upon synaptic activity, vesicular zinc is released from terminals enriched with ZnT3 and diffuses across the synaptic cleft 61 to modulate multiple postsynaptic receptors, 199,210 l including the zinc-sensitive N-methyl-d-aspartate receptor (NMDAR)
The clinical significance of this slight difference is debatable, but the effect is mentioned here as a possible off-target effect of DPP-4 inhibitors
its also about efficiency, recovery and consistency
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