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Chronic treatment with PARP inhibitors increased NAD + levels and mitochondrial respiration in 10-week-old mice and triggered UPR mt and increased mitochondrial respiration and lifespan in worms 109,257

Moreover, cysteinyl acetylation prevents the oxidation of the thiol group before its absorption

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Glutathione (GSH), also known as -glutamylcysteylglycine, is the most common small molecular weight thiol molecule generated in living cells (1)

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