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The system Xc-/GSH/GPX4 regulatory axis is regarded as the classical antioxidant regulatory axis of ferroptosis
Lizzo JM et al
Free copper ions generate reactive oxygen species through Fenton-like reactions
For example, in Hordeum vulgare leaves challenged with the powdery mildew fungus, Blumeria graminis , the fungal infection led to a significant decrease in APX and GR activity in whole-leaf extracts of resistant variety but caused no significant change in the susceptible one
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