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First, GIPR + neurons in the rat hindbrain are located primarily in both inhibitory and excitatory neurons in addition to some expression in oligodendrocytes (69, 87, 88), while GLP-1R is primarily expressed in excitatory neurons
SOCE supports calcium influx and orchestrates effector functions in microglia, including phagocytosis and cytokine release
Barbieri M, Bonafe M, Rizzo MR, Ragno E, Olivieri F, Marchegiani F, Franceschi C, Paolisso G
Until Wegovys MASH indication, patients with F2F3 fibrosis lacked any FDAapproved pharmacologic therapy targeting steatohepatitis resolution and fibrosis improvement, relying primarily on lifestyle modification and bariatric surgery. Against this background, semaglutides ability to deliver sustained doubledigit percentage weight loss, improve cardiometabolic markers, reduce MACE, and favorably modify histologic endpoints in MASH positions Wegovy as a versatile agent across cardiometabolic care pathways, provided its risks and limitations are fully understood and respected
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