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GLP-1 medications can help manage type 2 diabetes and obesity, but they may cause short-term mild-to-moderate side effects such as nausea, vomiting, diarrhoea, constipation, bloating, and decreased appetite, particularly at the beginning of treatment
These metabolic changes lead to glomerular hyperfiltration, enlargement, and increased proximal tubular glucose reabsorption via sodium-glucose cotransporter 2, resulting in elevated intraglomerular pressure and hyperfiltration [25]
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The indirect connection may relate to: The rate of weight loss achieved with Saxenda Changes in dietary patterns during treatment Alterations in fluid balance or hydration status Pre-existing risk factors that coincide with obesity Patients concerned about gout whilst taking Saxenda should discuss their individual risk profile with their GP or prescribing clinician, particularly if they have a personal or family history of gout or elevated uric acid levels
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