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The change in body weight was evaluated by the researchers, who then used mediation analysis to distinguish between the direct and indirect effects of weight reduction (mediated by GI AEs)
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Milligrams are a weight measurement of the active peptide
Exp Physiol 2007
Nonetheless, these symptoms led to discontinuation of treatment in 4-8% of patients enrolled in completed obesity trials for semaglutide (Novo Nordisk), and the dual GLP-1/GIP receptor agonist tirzepatide (Eli Lilly)
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