A more detailed mining of the A
Liu et al (33) demonstrated that chronic treatment with GLP-1 or AC3174 improves glucose metabolism, fluid balance and respiratory efficiency in a rat model of congestive heart failure, compared with vehicle control animals
Whilst the market is currently led by Novo Nordisks semaglutide (Ozempic/Wegovy) and Eli Lillys tirzepatide (Mounjaro/Zepbound), stronger competition is expected as new entrants including Boehringer Ingelheim, Amgen, Pfizer and Roche offer novel mechanisms (dual agonists, triple agonists and amylins), formulations (oral vs injectable) and dosing regimens (daily vs weekly vs monthly)
GLP-1 is a keystone hormone of metabolism with a wide range of metabolic effects, says Nicholas Norwitz, MD, a leading voice in the science of metabolic health
The GLP-1 hormone showed powerful glucose-lowering effects and appetite-suppressing properties, making it a prime candidate for therapeutic development