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As mentioned previously, cysteine is critical in the production of glutathione
Accordingly (and against accepted convention), the contribution of CYP2E1 to ALD pathophysiology may be more complex than originally thought and is likely dependent on the cellular microenvironment or subject to modulation by other signaling pathways 15,37
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Through -KG-dependent dioxygenase, the amino acid metabolite -KG is also involved in regulating histone and DNA demethylation (Xu et al., 2011
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