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Taken together these suggest that although GLP1R agonists may increase the risk of pancreatitis and thyroid cancer in rodents, that it has yet to be confirmed in humans

The recent rise in off-label use of semaglutide, particularly Ozempic, has led to drug shortages in several countries, including the United States, Canada, and Australia

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Pregnancy and lactation represent relative contraindications given absence of human safety data in these populations despite reassuring preclinical reproductive toxicology studies

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