tirzepatide vs semaglutide side effects differences UK: Mounjaro vs Wegovy Guide Semaglutide vs Tirzepatide: Which GLP-1

Blood clots can block blood flow in veins or arteries, leading to severe complications such as a heart attack or stroke

They are typically mild, manageable, and improve as the body adjusts

Exenatide (Byetta/Bydureon): Exenatide is an earlier-generation GLP-1 that is currently less expensive than semaglutide, but it needs to be administered more frequently and doesn't appear to have the same results in terms of weight loss and blood sugar control

At the other end of the spectrum (known as hardmaxxing), they "bone-smash" or have jaw surgery to "ascend" and reach a Neanderthal-like appearance

The New England Journal of Medicine , 384(2), 121131