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At 12 hours after APAP injection, the surviving rate of HFD fed mice was less than 10%, whereas over 80% of mice under control diet remained alive (Fig

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Notably, although the extent of weight loss is reduced in both CNS GLP-1R KO and CNS GIPR KO mice treated with mGIPR-Ab/GLP-1, it is not completely abolished, suggesting that each receptor contributes to the weight loss observed in control mGIPR-Ab/GLP-1-treated mice

In preclinical models of glaucoma and DR, GLP-1RAs have demonstrated robust neuroprotective effects in ocular tissues, primarily by modulating oxidative stress, inflammation, mitochondrial function, and synaptic plasticity [42, 43]